EGF Receptor in Tumor Growth and Progression

Members of the tyrosine kinase family are frequently implicated in experimental as well as in human cancer. The best studied receptor signaling system from this family is the EGF receptor. Experts in this area report on the involvement of the receptor in a variety of human tumors, outline underlying molecular mechanisms for aberrant receptor signaling in experimental systems and present the status of current therapies directed against the receptor. A detailed analysis of EGF receptor signal transduction via expression of receptor, ligands, phosphatases and presence of other members of the receptor family will provide new information for the design of therapeutic modalities targeting this receptor system.